2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione
Base Information
- Chemical Name: 2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione
- CAS No.: 19171-18-7
Factory Sells Best Quality 2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione 19171-18-7 with GMP standards
- Molecular Formula: C13H9N3O6
- Molecular Weight: 303.231
- Vapor Pressure: 1.63E-14mmHg at 25°C
- Melting Point: >200°C (dec.)
- Boiling Point: 603.4°Cat760mmHg
- PKA: 10.55±0.40(Predicted)
- Flash Point: 318.7°C
- PSA： 132.86000
- Density: 1.651g/cm3
- LogP: 0.73300
2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione(Cas 19171-18-7) Usage
InChI:InChI=1/C13H9N3O6/c17-9-5-4-8(11(18)14-9)15-12(19)6-2-1-3-7(16(21)22)10(6)13(15)20/h1-3,8H,4-5H2,(H,14,17,18)
19171-18-7 Relevant articles
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As a ubiquitous, highly pleiotropic and ...
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Steinebach, Christian,Lindner, Stefanie,Udeshi, Namrata D.,Mani, Deepak C.,Kehm, Hannes,K?pff, Simon,Carr, Steven A.,Gütschow, Michael,Kr?nke, Jan
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Here we present the rational design and ...
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Synthesis process for continuously preparing pomalidomide by using microchannel reactors
-
Paragraph 0055-0063, (2020/03/06)
The invention discloses a synthesis proc...
19171-18-7 Process route
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3-(4-nitro-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
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-
19171-18-7
4-NT
-
-
827026-45-9
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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1063995-54-9
3-(4-nitro-3-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
| Conditions | Yield |
|---|---|
|
With
potassium permanganate;
In
water;
at 50 - 70 ℃;
|
-
-
496-12-8
isoindoline
-
-
19171-18-7
4-NT
-
-
827026-45-9
3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
-
-
1063995-54-9
3-(4-nitro-3-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
3
steps
1: nitric acid; sulfuric acid / 8.5 h / 20 °C / Cooling with ice
2: copper(l) iodide; potassium carbonate / tetrahydrofuran / 6 h / 60 °C
3: potassium permanganate / water / 50 - 70 °C
With
potassium permanganate; copper(l) iodide; sulfuric acid; nitric acid; potassium carbonate;
In
tetrahydrofuran; water;
|
19171-18-7 Upstream products
-
641-70-3
3-nitrophthalic acid anhydride
-
24666-56-6
rac-α-aminoglutarimide hydrochloride
-
2650-64-8
Cbz-L-Gln
-
24666-55-5
3-(benzyloxycarbonyl)-amino-2,6-dioxopiperidine
19171-18-7 Downstream products
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19171-19-8
pomalidomide
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879126-98-4
Lenalidomide
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202271-89-4
(R)-(+)-4-amino-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3-dione
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202271-89-4
(S)-(-)-4-amino-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3-dione