Pazopanib
Base Information
- Chemical Name: Pazopanib
- CAS No.: 444731-52-6
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What is the Pazopanib ?
Pazopanib is White powder, while it's Molecular Formula is C21 H23 N7 O2 S. An oral angiogenesis inhibitor targeting VEGFR and PDGFR.
What is the CAS number for Pazopanib ?
The CAS number of Pazopanib is 444731-52-6.
More information of Pazopanib 444731-52-6 are:
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Synonyms |
5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide;GW 786034;Benzenesulfonamide,5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-;Votrient; |
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CAS?Number |
444731-52-6 |
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Molecular Formula |
C21 H23 N7 O2 S |
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Molecular Weight |
437.525 |
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Density |
1.40 g/cm3 |
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Melting Point |
285-289°C (dec.) |
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Boiling Point |
728.814 °C at 760 mmHg |
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Flash Point |
394.572 °C |
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HS CODE |
29350090 |
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PSA |
127.41000 |
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LogP |
4.99310 |
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Pka |
10.19±0.60(Predicted) |
What is Pazopanib (444731-52-6) used for?
Pazopanib is a multi-kinase inhibitor that inhibits the VEGF receptors VEGFR1, VEGFR2, and VEGFR3 (IC50s = 10, 30, and 47 nM, respectively, in a cell-free enzyme assay). It also inhibits PDGFRα, PDGFRβ, and c-Kit (IC50s = 71, 84, and 74 nM, respectively, in a cell-free enzyme assay) as well as additional receptor tyrosine kinases. Pazopanib inhibits upregulation of the surface adhesion proteins ICAM-1 and VCAM-1 induced by VEGF in multiple myeloma cells cocultured with human umbilical vein endothelial cells (HUVECs) and decreases multiple myeloma cell adhesion to HUVECs. It also inhibits proliferation of multiple myeloma cells cocultured with HUVECs. Pazopanib (30 and 100 mg/kg) reduces tumor growth, induces apoptosis, decreases angiogenesis, and increases survival in a multiple myeloma mouse xenograft model. Formulations containing pazopanib have been used in the treatment of cancer.
InChI:InChI=1/C21H23N7O2S.ClH/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16;/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);1H
Articles related to Pazopanib:
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Article |
Source |
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Switching on prodrugs using radiotherapy |
Geng, Jin,Zhang, Yichuan,Gao, Quan,Neumann, Kevin,Dong, Hua,Porter, Hamish,Potter, Mark,Ren, Hua,Argyle, David,Bradley, Mark , p. 805 - 810 (2021/06/14) |
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Pyrimidineamines as angiogenesis modulators |
- Paragraph 0345 - 0346, (2015/11/16) |
How to get the best price on Pazopanib?
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