Mycophenolate mofetil
Base Information
- Chemical Name: Mycophenolate mofetil
- CAS No.: 115007-34-6
Quality products?make an important contribution to long-term revenue and profitability. Quality manufacturer supply Mycophenolate mofetil 115007-34-6 in stock with high standard
1.What is the Mycophenolate mofetil ?
Mycophenolate mofetil (CellCept), in conjunction with cyclosporine and corticosteroids, has clinical applications in the prevention of organ rejection in patients receiving allogeneic renal and cardiac transplants. By effectively inhibiting de novo purine synthesis, it can impair the proliferation of both T and B lymphocytes. Following oral administration, mycophenolate mofetil is almost completely absorbed from the GI tract, metabolized in the liver first to the active compound mycophenolic acid, and then further metabolized to an inactive glucuronide. Early clinical trials indicate that mycophenolate mofetil in conjunction with cyclosporine and corticosteroids is a more effective regimen than azathioprine in preventing the acute rejection of transplanted organs. GI side effects are most common.
Mycophenolate Mofetil is an intermediate in the synthesis of (4Z)-Mycophenolate Mofetil (M831455), a degradation product of Mycophenolate mofetil, an immunosuppressant.
-
-
622-40-2
2-(morpholin-4-yl)ethanol
-
-
31858-66-9
methyl mycophenolate
-
-
115007-34-6
mycophenolate mofetil
| Conditions | Yield |
|---|---|
|
di(n-butyl)tin oxide;
In
toluene;
at 120 ℃;
for 24h;
|
89.5%
|
|
2-(morpholin-4-yl)ethanol;
With
sodium ethanolate;
In
ethanol;
at 0 - 25 ℃;
methyl mycophenolate;
In
toluene; xylene;
at 20 - 145 ℃;
Product distribution / selectivity;
|
85%
|
|
In
ethyl acetate;
at 20 ℃;
for 0.5h;
|
81%
|
|
tin(ll) chloride;
at 150 - 160 ℃;
for 9h;
Product distribution / selectivity;
|
77%
|
|
zinc diacetate;
at 90 - 100 ℃;
for 18 - 32h;
under 80 - 100 Torr;
Product distribution / selectivity;
|
|
|
calcium;
at 125 - 130 ℃;
Product distribution / selectivity;
|
|
|
calcium oxide;
at 125 - 130 ℃;
Product distribution / selectivity;
|
|
|
zinc;
at 125 - 130 ℃;
for 35 - 44h;
Product distribution / selectivity;
|
|
|
zinc(II) oxide;
at 125 - 130 ℃;
for 40h;
Product distribution / selectivity;
|
|
|
zinc(II) chloride;
at 115 - 120 ℃;
for 38 - 40h;
Product distribution / selectivity;
|
|
|
calcium chloride;
at 125 - 130 ℃;
Product distribution / selectivity;
|
-
-
622-40-2
2-(morpholin-4-yl)ethanol
-
-
24280-93-1
mycophenolic acid
-
-
115007-34-6
mycophenolate mofetil
| Conditions | Yield |
|---|---|
|
toluene-4-sulfonic acid;
at 160 ℃;
for 5h;
Product distribution / selectivity;
|
84%
|
|
(1S)-10-camphorsulfonic acid;
at 150 - 155 ℃;
for 8h;
Product distribution / selectivity;
|
84%
|
|
at 160 ℃;
for 5h;
Product distribution / selectivity;
|
84%
|
|
2-(morpholin-4-yl)ethanol;
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
ethyl acetate;
at 0 - 10 ℃;
for 0.25h;
Inert atmosphere;
mycophenolic acid;
In
ethyl acetate;
at 0 - 20 ℃;
for 6h;
Reagent/catalyst;
Solvent;
Temperature;
Inert atmosphere;
|
75%
|
|
2-(morpholin-4-yl)ethanol;
With
sodium methylate;
In
methanol; toluene;
at 20 - 70 ℃;
mycophenolic acid;
In
methanol; toluene;
at 110 ℃;
|
70%
|
|
zinc(II) sulfate;
at 160 - 165 ℃;
for 4h;
Product distribution / selectivity;
|
68%
|
|
tin(ll) chloride;
at 150 - 180 ℃;
for 1.5 - 4h;
Product distribution / selectivity;
|
65%
|
|
potassium dihydrogenphosphate;
at 165 ℃;
for 3h;
Product distribution / selectivity;
|
62%
|
|
sulfuric acid;
In
toluene;
for 0.5h;
silica gel support
Microwave irridation;
|
57%
|
|
for 1.66667h;
silica gel support
Microwave irridation;
|
52%
|
|
sulfuric acid;
In
toluene;
for 0.5h;
Microwave irridation;
|
37.3%
|
|
In
toluene; xylene;
for 0.5h;
Microwave irridation;
|
23%
|
|
for 0.5h;
bentonite support
Microwave irridation;
|
10%
|
|
In
toluene;
for 0.5h;
silica gel support
Microwave irridation;
|
24 %Chromat.
|
|
In
toluene;
at 110 - 120 ℃;
for 24h;
Product distribution / selectivity;
Drying agent (sodium sulfate);
|
|
|
In
toluene;
at 110 - 120 ℃;
for 24h;
Product distribution / selectivity;
Drying agent (magnesium sulfate);
|
|
|
With
2,2'-dipyridyl carbonate;
dmap;
In
toluene;
at 20 ℃;
for 10 - 24h;
Product distribution / selectivity;
|
|
|
With
2,2'-dipyridyl carbonate;
dmap;
In
dichloromethane;
at 20 ℃;
for 24h;
Product distribution / selectivity;
|
|
|
With
2,2'-dipyridyl carbonate;
dmap;
at 20 ℃;
for 24h;
Product distribution / selectivity;
|
|
|
2-(morpholin-4-yl)ethanol; mycophenolic acid;
In
N,N-dimethyl-formamide;
at 120 - 130 ℃;
Molecular sieve;
With
hydrogenchloride;
In
water;
pH=2 - 2.5;
With
sodium carbonate;
In
water;
pH=8 - 8.5;
|
2.What is the CAS number for Mycophenolate mofetil ?
The CAS number of Mycophenolate mofetil is 115007-34-6.
More information of Mycophenolate mofetil 115007-34-6 are:
|
CAS?Number |
115007-34-6 |
|
Density |
1.222 g/cm3 |
|
Melting Point |
93-94oC |
|
Boiling Point |
637.6oC at 760 mmHg |
|
Flash Point |
339.4oC |
|
Vapor Pressure |
7.51E-17mmHg at 25°C |
|
Refractive Index |
1.557 |
|
HS CODE |
2934999090 |
|
PSA |
94.53000 |
|
LogP |
2.46190 |
3.What are another words for Mycophenolate mofetil ?
Synonyms?for?Mycophenolate mofetil 115007-34-6:2-(4-Morpholinyl)ethyl 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-4-hexenoate;Mycophenolate mofetil;
4.What is the molecular formula of Mycophenolate mofetil?
The chemical formula of ?Mycophenolate mofetil is?C23H31NO7 which containing 23 Carbon atoms,31 Hydrogen atoms,1 Nitrogen atoms and 7 Oxygen atoms,and the molecular weight of??Mycophenolate mofetil?is 433.502.
5.What is Mycophenolate mofetil (115007-34-6) used for?
Mycophenolate mofetil (MMF), also known as Cellcept, is a semisynthetic derivative of mycophenolic acid (MPA), which is derived from the glycolysis product of the mold Penicillin glaucum. It is a white or almost white, crystalline powder with a history of clinical application for over 10 years. MMF is an immunosuppressant and an inhibitor of nucleic acid synthesis, used primarily for the prevention of allograft rejection reactions in organ transplants and the treatment of various autoimmune diseases.
InChI:InChI=1/C23H31NO7/c1-15(5-7-19(25)30-13-10-24-8-11-29-12-9-24)4-6-17-21(26)20-18(14-31-23(20)27)16(2)22(17)28-3/h4,26H,5-14H2,1-3H3
Relevant articles related to Mycophenolate mofetil:
|
Article |
Source |
|
USAGE OF MYCOPHENOLATE MOFETIL OR SALT THEREOF IN PREPARING DRUG FOR RESISTING AGAINST INFLUENZA VIRUS |
- Paragraph 0047, (2016/03/14) |
|
PROCESS FOR PREPARING MYCOPHENOLATE MOFETIL |
- Page/Page column 13-14, (2009/08/14) |
6.Buy Mycophenolate mofetil with the best price .
Shanghai chamflyer chemicals Co., Ltd is a quality supplier of Mycophenolate mofetil. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Mycophenolate mofetil 115007-34-6.