Azilsartan
Base Information
- Chemical Name: Azilsartan
- CAS No.: 147403-03-0
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What is the Azilsartan ?
Azilsartan is , while it's Molecular Formula is C25H20N4O5. Azilsartan is an angiotensin II type 1 (AT1) receptor antagonist with IC50 of 2.6 nM
What is the CAS number for Azilsartan ?
The CAS number of Azilsartan is 147403-03-0.
More information of Azilsartan 147403-03-0 are:
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Synonyms |
see 1H-Benzimidazole-7-carboxylic acid,1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol- 3-yl)[1,1'-biphenyl]-4-yl]methyl]-2- ethoxy-;TAK 536;2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid; |
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CAS?Number |
147403-03-0 |
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Molecular Formula |
C25H20N4O5 |
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Molecular Weight |
456.458 |
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Density |
1.42 cm3 |
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Melting Point |
188 °C(dec.) |
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PSA |
123.24000 |
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LogP |
4.19180 |
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Pka |
2.05±0.10(Predicted) |
What is Azilsartan (147403-03-0) used for?
Azilsartan is an antagonist of the angiotensin II type 1 receptor (AT1; IC50 = 0.42 μM) and the active metabolite of azilsartan medoxomil . Azilsartan is formed from azilsartan medoxomil by hydrolysis in the gastrointestinal tract and liver. Azilsartan also acts as an inverse agonist, inhibiting angiotensin II-induced accumulation of inositol-1-phosphate in COS-7 cells expressing recombinant human AT1 (IC50 = 2.6 nM). It reduces the maximal contractile response induced by angiotensin II in isolated rabbit aortic strips (pD2 = 9.9). Azilsartan (100 ng/kg, i.v.) inhibits the angiotensin II-induced pressor response in conscious normotensive rats.
Articles related to Azilsartan:
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Article |
Source |
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Liquid chromatography/tandem mass spectrometry study of forced degradation of azilsartan medoxomil potassium |
Swain, Debasish,Patel, Prinesh N.,Palaniappan, Ilayaraja,Sahu, Gayatri,Samanthula, Gananadhamu , p. 1437 - 1447 (2015) |
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AZILSARTAN ALKYL ESTER, METHOD FOR PRODUCING AZILSARTAN METHYL ESTER, AND METHOD FOR PRODUCING AZILSARTAN |
- , (2021/04/17) |
How to get the best price on Azilsartan?
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