1,3-Dihydro-5-phenyl-1,4-benzodiazepin-2-one
Base Information
- Chemical Name: 1,3-Dihydro-5-phenyl-1,4-benzodiazepin-2-one
- CAS No.: 2898-08-0
Factory Sells Best Quality 1,3-Dihydro-5-phenyl-1,4-benzodiazepin-2-one 2898-08-0 with steady supply
- Molecular Formula: C15H12 N2 O
- Molecular Weight: 236.273
- Vapor Pressure: 2.08E-07mmHg at 25°C
- Melting Point: 170-180 °C
- Boiling Point: 424.4 °C at 760 mmHg
- PKA: pKa 4.17/12.49(2% aq. EtOH,t =25) (Uncertain)
- Flash Point: 210.5 °C
- PSA： 41.46000
- Density: 1.21 g/cm3
- LogP: 2.04970
1,3-Dihydro-5-phenyl-1,4-benzodiazepin-2-one(Cas 2898-08-0) Usage
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General Description |
1,3-Dihydro-5-phenyl-1,4-benzodiazepin-2-one, also known as phenazepam, is a psychoactive drug belonging to the benzodiazepine class of medications. It is a potent sedative, anxiolytic, and muscle relaxant. Phenazepam is known for its high potency, long duration of action, and strong sedative effects, making it a potentially dangerous substance when misused or abused. It has been used for the treatment of anxiety, insomnia, and seizures, but it is not commonly prescribed due to its potential for misuse and addiction. It is considered a controlled substance in many countries and is classified as a Schedule IV controlled substance in the United States. Phenazepam has been linked to several cases of overdose and death, and its use should be strictly monitored and regulated by medical professionals. |
InChI:InChI=1/C15H12N2O/c18-14-10-16-15(11-6-2-1-3-7-11)12-8-4-5-9-13(12)17-14/h1-9H,10H2,(H,17,18)
2898-08-0 Relevant articles
Synthesis and biological evaluation of benzodiazepines containing a pentafluorosulfanyl group
Jose, Arathy,Tareque, Raysa Khan,Mortensen, Martin,Legay, Remi,Coles, Simon J.,Tizzard, Graham J.,Greenland, Barnaby W.,Smart, Trevor G.,Bagley, Mark C.,Spencer, John
, (2021)
The widely used pentafluorosulfanyl grou...
TRICYCLIC CRBN LIGANDS AND USES THEREOF
-
Paragraph 0776; 0778, (2020/01/24)
The present invention provides compounds...
Structure-Activity Relationship Studies of Retro-1 Analogues against Shiga Toxin
Abdelkafi, Hajer,Michau, Aurélien,Pons, Valérie,Ngadjeua, Flora,Clerget, Alexandra,Ait Ouarab, Lilia,Buisson, David-Alexandre,Montoir, David,Caramelle, Lucie,Gillet, Daniel,Barbier, Julien,Cintrat, Jean-Christophe
, p. 8114 - 8133 (2020/09/21)
High-throughput screening has shown that...
Simple synthetic process of quazepam intermediate
-
Paragraph 0015-0017, (2019/05/08)
The invention discloses a simple synthet...
2898-08-0 Process route
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598-21-0
2-Bromoacetyl bromide
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2835-77-0
(2-aminophenyl)(phenyl)methanone
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-
2898-08-0
2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one
| Conditions | Yield |
|---|---|
|
2-Bromoacetyl bromide; (2-aminophenyl)(phenyl)methanone;
With
sodium hydrogencarbonate;
In
chloroform;
at 0 ℃;
With
ammonia;
In
methanol;
at 0 - 20 ℃;
Heating / reflux;
|
83%
|
|
2-Bromoacetyl bromide; (2-aminophenyl)(phenyl)methanone;
In
dichloromethane; water;
With
ammonia;
|
|
|
With
sodium hydroxide;
In
dichloromethane;
|
-
-
23207-75-2
N-(2-benzoylphenyl)-2-chloroacetamide
-
-
2898-08-0
2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one
| Conditions | Yield |
|---|---|
|
With
hexamethylenetetramine; ammonium acetate;
In
ethanol;
for 6h;
Reflux;
|
95%
|
|
With
hexamethylenetetramine;
In
ethanol; chloroform;
|
86%
|
|
With
paraformaldehyde;
In
methanol; toluene;
|
84.7%
|
|
With
hexamethylenetetramine; ammonium chloride;
In
ethanol;
for 4h;
Reflux;
|
50%
|
|
Multi-step reaction
with
2
steps
1: sodium azide / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere
2: diphenylsilane; 9-phenyl-9-phosphafluorene / 1,4-dioxane / 16 h / 101 °C / Inert atmosphere
With
sodium azide; 9-phenyl-9-phosphafluorene; diphenylsilane;
In
1,4-dioxane; N,N-dimethyl-formamide;
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2898-08-0 Upstream products
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14439-71-5
2'-benzoyl-2-bromo-acetanilide
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100-97-0
hexamethylenetetramine
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23207-75-2
N-(2-benzoylphenyl)-2-chloroacetamide
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616-34-2
methoxycarbonylmethylamine
2898-08-0 Downstream products
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3034-65-9
1-methyl-2,3-dihydro-2-oxo-5-phenyl-1,4-benzodiazepine
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117047-24-2
6-Phenyl-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid ethyl ester
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34099-69-9
1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-thione
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145084-43-1
1,3-dihydro-1-(2'-methylphenacyl)-5-phenyl-2H-1,4-benzodiazepin-2-one