(3,4-Dimethoxyphenyl)acetic acid
Base Information
- Chemical Name: (3,4-Dimethoxyphenyl)acetic acid
- CAS No.: 93-40-3
Factory Sells Best Quality (3,4-Dimethoxyphenyl)acetic acid 93-40-3 with ISO standards
- Molecular Formula: C10H12O4
- Molecular Weight: 196.203
- Appearance/Colour: white to beige powder
- Vapor Pressure: 6.23E-05mmHg at 25°C
- Melting Point: 96-98 °C(lit.)
- Refractive Index: 1.5430 (estimate)
- Boiling Point: 331.4 °C at 760 mmHg
- PKA: pK1:4.333 (25°C)
- Flash Point: 130.2 °C
- PSA： 55.76000
- Density: 1.189 g/cm3
- LogP: 1.33090
(3,4-Dimethoxyphenyl)acetic acid(Cas 93-40-3) Usage
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Synthesis Reference(s) |
Organic Syntheses, Coll. Vol. 2, p. 333, 1943The Journal of Organic Chemistry, 15, p. 548, 1950 DOI: 10.1021/jo01149a016 |
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Purification Methods |
Crystallise homoveratric acid from H2O or *C6H6/ligroin. The amide has m 142o (from H2O). [Beilstein 10 H 409, 10 I 197, 10 II 268, 10 III 1459, 10 IV 1509.] |
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General Description |
(3,4-Dimethoxyphenyl)acetic acid, also known as homoveratric acid, is a key starting compound used in the synthesis of benzo[c]pyrilium salts with cyclopolyether substituents. It reacts with benzo-15-crown-5 in polyphosphoric acid to form a ketone intermediate, which is further converted into benzo[c]pyrilium perchlorates and subsequently into isoquinoline derivatives. These derivatives are studied for their potential biological activity, particularly in membrane penetration and selective ion transfer. |
InChI:InChI=1/C10H12O4/c1-13-8-4-3-7(6-10(11)12)5-9(8)14-2/h3-5H,6H2,1-2H3,(H,11,12)/p-1
93-40-3 Relevant articles
A modular and divergent approach to spirocyclic pyrrolidines
Dixon, Darren J.,Ogura, Yusuke,Shennan, Benjamin D. A.,Smith, Peter W.
, p. 10354 - 10360 (2020)
An efficient three-step sequence to affo...
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Schmalfuss
, p. 112,117, 118 (1937)
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Polycarboxylated compounds and compositions containing same
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Page/Page column 17-22, (2021/06/09)
Methods of selectively modifying lignin,...
Synthesis and biological evaluation of 3-arylcoumarin derivatives as potential anti-diabetic agents
Hu, Yuheng,Wang, Bing,Yang, Jie,Liu, Teng,Sun, Jie,Wang, Xiaojing
, p. 15 - 30 (2018/10/31)
A variety of substituted 3-arylcoumarin ...
Synthesis and biological evaluation of 3-arylcoumarins as potential anti-Alzheimer's disease agents
Yang, Jie,Zhang, Pingping,Hu, Yuheng,Liu, Teng,Sun, Jie,Wang, Xiaojing
, p. 651 - 656 (2019/02/19)
Alzheimer's disease, a neurodegenerative...
93-40-3 Process route
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C18 H20 O5 S
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93-40-3
(3,4-Dimethoxyphenyl)acetic acid
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93-07-2
Veratric acid
| Conditions | Yield |
|---|---|
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With
ammonium cerium (IV) nitrate; oxygen;
In
acetonitrile;
at 20 - 50 ℃;
for 4h;
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30%
55% |
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93-15-2
1,2-dimethoxy-4-(2-propenyl)benzene
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93-40-3
(3,4-Dimethoxyphenyl)acetic acid
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93-07-2
Veratric acid
| Conditions | Yield |
|---|---|
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With
potassium permanganate; acetone;
at 0 ℃;
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93-40-3 Upstream products
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186581-53-3
diazomethane
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102-32-9
3,4-dihydroxyphenylacetate
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93-15-2
1,2-dimethoxy-4-(2-propenyl)benzene
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93-17-4
3,4-dimethoxyphenylacetonitrile
93-40-3 Downstream products
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71642-80-3
2-(3,4-dimethoxyphenyl)-1-(piperidin-1-yl)ethan-1-one
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15964-79-1
methyl (3,4-dimethoxyphenyl)acetate
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3979-57-5
(3,4-dimethoxy-phenyl)-acetic acid-[2-(3,4-dimethoxy-phenyl)-1-methyl-ethylamide]
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18066-68-7
ethyl 3,4-dimethoxyphenylacetate